TCS Daily


Those Dirty Rats

By Duane D. Freese - February 21, 2006 12:00 AM

Here's some advice: If you want to avoid getting cancer, die young.

And if you're a journalist, here's some more: if you want to make a big splash about the above fact, spin it with an old story linking cancer to a popular food ingredient and wed that to 30-year-old alleged cover up.

That's essentially what The New York Times did in a 2,600-word expose in its Sunday, Feb. 12, paper.

"The Lowdown on Sweet?" by Melanie Warner has overshadowed the good news on the cancer front this month, the American Cancer Society reporting a decrease in the actual number of cancer deaths for the first time in 70 years and New York University researchers discovering a protein known to cause cancer can be manipulated, providing hopes for better cancer therapies.

Which is a bit sad, really, as this is the third go round for this scare. The basis of this old new story is a six-month old study by the European Ramaziini Foundation of Italy. In the study, researchers fed rats various levels of aspartame - the stuff in Equal and Nutrasweet and most modern diet pop and many diet foods. A group of 150 males and females each got none, zero, zip. Another 150 males and females got the equivalent of 4 milligrams per kilogram of body weight, or a can and a half a day. The other groups split up into 100 male and female pairs got levels of 20 mg/kg, or 7 cans; 100mg, 35 cans; 500mg, 175 cans; 2500 mg, 875 cans, and finally 5,000 mg, or the equivalent of 1,750 cans a day.

Food safety agencies have set the safe level of aspartame consumption at 40 to 50 mg a day, 15 to 18 cans. The big thing about the study was that it claimed its autopsies of the rats after they died found a significant increase in lymphomas and leukemias among the female rats, though not the male rats, at 7 cans a day. Mercy.

When the news first broke last July with publication of the study in the European Journal of Oncology, the Times didn't report it but other news organizations in Europe and here headlined its claim of a link between the sweetener and cancer while the usual consumer advocates demanded action by food safety agencies to protect the public.

Then a few months passed, and the Ramazzini study was published again in the November Environmental Health Perspectives, spurring another round of news stories and hand wringing.

By then, though, the sweetener industry was beginning to raise questions about the study. For example, unlike other studies that kill off the rats after two years and count the tumors, the Ramazzini study waited for them to die. "Rats, like people, develop a wide range of cancers in old age, and establishing whether there is a cause-and-effect relationship (at an age when cancers are common) is not possible," Joe Poulos, a spokesman for Merisant, maker of Equal, told Fox News.

Further, the regulatory agencies were taking a look at the published studies and raising questions, too. The Committee on Carcinogenicity in the United Kingdom at its December meeting made one telling statement: "There are slight differences in historical control data for the incidences of lymphomas and leukaemias in female rats between the published data (average 13.4%, range 7.0-18.4%) and data presented to the EFSA (European Food Safety Authority) on 17 June 2005 (average 12.9%, range 4-25%). The incidences of lymphomas and leukaemias in female aspartame-fed rats occurred over the range of the historical control data sets presented in the paper. Members considered that a small increase a tumour incidence over such a wide range of doses was implausible."

In other words, the Ramazzini study's cancer rates for the aspartame fed rats fit in the range of cancers that the institute had historically found for its control rats. Furthermore, the cancer rates for the aspartame fed females remained pretty stable no matter the dosage. If aspartame were toxic, you would expect the rate of cancers to increase as the dosage increased.

Warner's editors let her ramble on for more than 600 words about the approval process, noting that "from 1977 to 1985 — during much of the approval process — (G.D.) Searle (which invented aspartame) was headed by Donald H. Rumsfeld, who is now the secretary of defense," and then running through a litany of supposed revolving door relationships and a lot of innuendo about a possible cover-up.

All of which is a bit bizarre, considering that Congress' Government Accounting Office (now Government Accountability Office) in 1987, on a request from Ohio Democratic Sen. Howard Metzenbaum, reported that the FDA had followed appropriate procedures in its approvals. Aspartame has received significant scrutiny in studies for use in Europe, Canada and other places as well.

Warner and the Times might have better spent their time looking at the Ramazzini study itself, in particular its charts on rat survival rates. There's something peculiar about them. An email to Ramazzini about the peculiarity has yet to be answered; but then, as Dr. George Pauli of the FDA told the Times, the agency "requested the data from the Ramazzini study in July 2005 but we have as not yet received the data."

Like Pauli, I wouldn't draw any conclusions from the charts until I hear more from Ramazzini - other than to note that at the 104 week mark, the charts show only 40% of the.control rats had survived and at week 120, only 15% were alive. Many researchers believe experiments with rats should be ended when the control group falls below 20%, so as not to skew cancer counting results.

Here's what's even stranger: the rats with the highest survival rates at 104 and 120 weeks, at 55% and about 29% respectively, were the rats that ate the most aspartame - the equivalent of 1,750 cans of diet soda a day. And the longest living rat of all consumed the equivalent of 175 cans a day. In short, the control rats died first; the heavy aspartame consumers lived longest.

Looks like if you want to increase your odds of living a long life, be prepared to burp.

Duane Freese is Deputy Editor of TCS Daily.

Categories:

9 Comments

aspartame (Equal,NutraSweet) poisoning

aspartame (Equal,NutraSweet) poisoning
Deardfreese,

You are so very ill informed. Just do your readers a favor... check out the real facts at Dr. Janet Hull's www.sweetpoison.com and www.presidiotex.com/aspartame. Read the Bressler Report. Dr. Bressler and his FDA team a tissue trail of lies about Searle's tests on ****topiperzine in the the 1970's

The Barcelona Report is there too... The team proved that the methanol in aspartame converts to formaldehyde and collects in the liver. The formaldehyde then converts to formic acid and attacks the retina in the eye.

Furthermore, in 1993, the FDA was forced to reveal under the Freedom of Information Act 93 symptoms caused by aspartame... seizure, memory loss, and death among them.

So what is it with you to be so very dense or uninformed; ususally when people such as you write they are attached to the industry and are protecting them.

There is a list on yahoo called the aspartame victim support group. Since 1998, the number of listers has held steady with a 1,000 members... Victims come and go and my dear man, they can't all be hallucinating or making up their symtpoms.

Get real. If you are a user, I understand--the methanol in aspartame is addictive and very hard to give up.

Pity. You're not a bad writer.

Carol Guilford
Author: The New Cooks Bookbook, THE Diet Book, Carol Guilford's Main Course Cookbook, The Easiest Cookbook.

I won't post this to the list... Everyone on it knows Dr. Soffritti of the Ramazzini Institute is a hero, not you.

mainstream research on aspartame (methanol, formaldehyde, formic acid toxicity)

http://groups.yahoo.com/group/aspartameNM/message/1306
ban aspartame speech, Roger Williams MP, UK Parliament 2005.12.14:
www.TheyWorkForYou.com: Murray 2006.02.20

February 21, 2006

"Of course, everyone chooses, as a natural priority,
to actively find, quickly share, and act upon the facts
about healthy and safe food, drink, and environment."

Rich Murray, MA Room For All rmforall@comcast.net
505-501-2298 1943 Otowi Road Santa Fe, New Mexico 87505

http://groups.yahoo.com/group/aspartameNM/messages
group with 151 members, 1,306 posts in a public, searchable archive
http://RMForAll.blogspot.com http://AspartameNM.blogspot.com

Dark wines and liquors, as well as aspartame, provide
similar levels of methanol, above 120 mg daily, for
long-term heavy users, 2 L daily, about 6 cans.

Methanol is inevitably largely turned into formaldehyde,
and thence largely into formic acid.
It is the major cause of the dreaded symptoms of "next
morning" hangover.

Fully 11% of aspartame is methanol -- 1,120 mg aspartame
in 2 L diet soda, almost six 12-oz cans, gives 123 mg
methanol (wood alcohol). If 30% of the methanol is turned
into formaldehyde, the amount of formaldehyde, 37 mg,
is 18.5 times the USA EPA limit for daily formaldehyde in
drinking water, 2.0 mg in 2 L average daily drinking water.

http://groups.yahoo.com/group/aspartameNM/message/1108
faults in 1999 July EPA 468-page formaldehyde profile:
Elzbieta Skrzydlewska PhD, Assc. Prof., Medical U. of
Bialystok, Poland, abstracts -- ethanol, methanol,
formaldehyde, formic acid, acetaldehyde, lipid peroxidation,
green tea, aging: Murray 2004.08.08 2005.07.11

http://groups.yahoo.com/group/aspartameNM/message/835
ATSDR: EPA limit 1 ppm formaldehyde in drinking water July
1999: Murray 2002.05.30 rmforall

http://groups.yahoo.com/group/aspartameNM/message/1143
methanol (formaldehyde, formic acid) disposition: Bouchard M
et al, full plain text, 2001: substantial sources are
degradation of fruit pectins, liquors, aspartame, smoke:
Murray 2005.04.02

Any unsuspected source of methanol, which the body always quickly
and largely turns into formaldehyde and then formic acid, must be
monitored, especially for high responsibility occupations, often with
night shifts, such as pilots and nuclear reactor operators.

In particular, the next review gives many recent mainstream
peer-reviewed studies that show formaldehyde,
always inevitably derived in the body from any methanol source,
including aspartame, causes endothelial injury,
ie, diabetic neuropathy -- among the most serious and complex
complications of diabetes.

http://groups.yahoo.com/group/aspartameNM/message/1263
many studies on endothelial injury (diabetic neuropathy) by adducts of
formaldehyde derived from methylamine from many of the same sources
as also supply methanol (formaldehyde), including aspartame:
PH Yu et al: DJ Conklin et al: Murray 2005.12.04

http://groups.yahoo.com/group/aspartameNM/message/1291
European Food Safety Authority to decide aspartame safety by May:
caffeine diet drinks cause female hypertension, WC Winkelmayer et al,
JAMA 2005.11.09: PubMed lists 50 items for "diet soft drinks" since
2004 Oct.: Murray 2006.01.24

http://groups.yahoo.com/group/aspartameNM/message/1279
all three aspartame metabolites harm human erythrocyte [red blood cell]
membrane enzyme activity, KH Schulpis et al, two studies in 2005,
Athens, Greece, 2005.12.14: 2004 research review, RL Blaylock:
Murray 2006.01.14

http://groups.yahoo.com/group/aspartameNM/message/939
aspartame (aspartic acid, phenylalanine) binding to DNA:
Karikas July 1998: Murray 2003.01.05 rmforall
Karikas GA, Schulpis KH, Reclos GJ, Kokotos G
Measurement of molecular interaction of aspartame and
its metabolites with DNA. Clin Biochem 1998 Jul; 31(5): 405-7.
Dept. of Chemistry, University of Athens, Greece
http://www.chem.uoa.gr gkokotos@atlas.uoa.gr;
K.H. Schulpis inchildh@otenet.gr; G.J. Reclos reklos@otenet.gr;

http://groups.yahoo.com/group/aspartameNM/message/1271
combining aspartame and quinoline yellow, or MSG and brilliant blue,
harms nerve cells, eminent C. Vyvyan Howard et al, 2005
education.guardian.co.uk, Felicity Lawrence: Murray 2005.12.21

http://groups.yahoo.com/group/aspartameNM/message/1277
50% UK baby food is now organic -- aspartame or MSG
with food dyes harm nerve cells, CV Howard 3 year study
funded by Lizzy Vann, CEO, Organix Brands,
Children's Food Advisory Service: Murray 2006.01.13

http://groups.yahoo.com/group/aspartameNM/message/925
aspartame puts formaldehyde adducts into tissues, Part 1/2
full text Trocho & Alemany 1998.06.26
Universitat Autònoma de Barcelona : Murray 2002.12.22

http://groups.yahoo.com/group/aspartameNM/message/1250
aspartame causes cancer in rats at levels approved for humans,
Morando Soffritti et al, Ramazzini Foundation, Italy &
National Toxicology Program
of National Institute of Environmental Health Sciences
2005.11.17 Env. Health Pers. 35 pages: Murray

http://groups.yahoo.com/group/aspartameNM/message/1226
USA National Institutes of Health National Toxicology
Program aids eminent Ramazzini Foundation, Bologna, Italy,
in more results on cancers in rats from lifetime low levels
of aspartame (methanol, formaldehyde), Felicity Lawrence,
www.guardian.co.uk: Murray 2005.09.30

http://groups.yahoo.com/group/aspartameNM/message/1186
aspartame induces lymphomas and leukaemias in rats, full plain text,
M Soffritti, F Belpoggi, DD Esposti, L Lambertini: Ramazzini
Foundation study 2005.07.14: main results agree with their previous
methanol and formaldehyde studies: Murray 2005.09.03

http://groups.yahoo.com/group/aspartameNM/message/1189
Michael F Jacobson of CSPI now and in 1985 re aspartame
toxicity, letter to FDA Commissioner Lester Crawford;
California OEHHA aspartame critique 2004.03.12; Center for
Consumer Freedom denounces CSPI: Murray 2005.07.27
*******************************************************

http://groups.yahoo.com/group/aspartameNM/message/1286
methanol products (formaldehyde and formic acid) are main cause of
alcohol hangover symptoms [same as from similar amounts of
methanol, the 11% part of aspartame]: YS Woo et al, 2005 Dec:
Murray 2006.01.20

http://groups.yahoo.com/group/aspartameNM/message/1106
hangover research relevant to toxicity of 11% methanol in aspartame
(formaldehyde, formic acid): Calder I (full text): Jones AW:
Murray 2004.08.05 rmforall

Since no adaquate data has ever been published on the exact disposition
of toxic metabolites in specific tissues in humans of the 11% methanol
component of aspartame, the many studies on morning-after hangover
from the methanol impurity in alcohol drinks are the main available
resource to date.

Jones AW (1987) found next-morning hangover from red wine with
100 to 150 mg methanol
(9.5% w/v ethanol, 100 mg/l methanol, 0.01%,
one part in ten thousand).

Fully 11% of aspartame is methanol --
1,120 mg aspartame in 2 L diet soda, almost six 12-oz cans,
gives 123 mg methanol (wood alcohol) --
the same amount that produces hangover from red wine.

The expert review by Monte WC (1984) states:
"An alcoholic consuming 1500 calories a day from alcoholic sources
alone may consume between 0 and 600 mg of methanol e

aspartame (methanol, formaldehyde, formic acid) toxicity continued
The expert review by Monte WC (1984) states:
"An alcoholic consuming 1500 calories a day from alcoholic sources
alone may consume between 0 and 600 mg of methanol each day
depending on his choice of beverages (Table 1)...."
Table 1 lists red wine as having 128 mg/l methanol,
about one part in ten thousand.

An editorial review by Ian Calder, F.R.C.A.,
"Hangovers: not the ethanol-- perhaps the methanol",
British Medical Journal 1997 Jan 4; 314(7073): 2
[Tel/Fax: 0171 720 9279
Consultant Anaesthetist at the National Hospital
for Neurology and Neurosurgery, London WCIN 3BG, UK]
http://bmj.bmjjournals.com/search.dtl search to get free full text ],
states:

"In fact, ethanol itself may play only a minor part in producing the thirst,
headache, fatigue, nausea, sweating, tremor, remorse, and anxiety that
hangover sufferers report.... [ Also, dizziness is common. ]

"Between a quarter and a half of drinkers claim not to experience
hangover symptoms despite having been intoxicated. (three citations)"

The symptom list is similar to reports by aspartame reactors.

If only a fraction of aspartame users happen to be vulnerable to the
methanol, that would account well for the disbelief by those who are
not aspartame reactors, as well as the scientific difficulty in proving
aspartame toxicity in the general population.

Research can study whether the hangover prone are also vulnerable to
aspartame, methanol, formaldehyde, and formic acid, and determine
the specific biochemistry for different groups.

Hangover treatments may help aspartame reactors. For instance,
adaquate folic acid (folate) helps humans eliminate the toxic products
from methanol.

Reprod Toxicol. 1996 Nov-Dec; 10(6): 455-63.
Influence of dietary folic acid on the developmental toxicity of methanol
and the frequency of chromosomal breakage in the CD-1 mouse.
Fu SS, Sakanashi TM, Rogers JM, Hong KH, Keen CL.
Department of Nutrition, University of California, Davis 95616, USA.

"These results show that marginal folate deficiency in pregnant dams
significantly increases the teratogenicity of MeOH." PMID: 8946559
*******************************************************

http://groups.yahoo.com/group/aspartameNM/message/870
Aspartame: Methanol and the Public Interest 1984: Monte:
Murray 2002.09.23

Dr. Woodrow C. Monte Aspartame: methanol, and the public health.
Journal of Applied Nutrition 1984; 36 (1): 42-54.
(62 references) Professsor of Food Science [retired 1992]
Arizona State University, Tempe, Arizona 85287
woodymonte@xtra.co.nz
The methanol from 2 L of diet soda, 5.6 12-oz cans, 20 mg/can, is
112 mg, 10% of the aspartame.
The EPA limit for water is 7.8 mg daily for methanol (wood alcohol), a
deadly cumulative poison.
Many users drink 1-2 L daily.
The reported symptoms are entirely consistent with chronic methanol
toxicity. (Fresh orange juice has 34 mg/L, but, like all juices, has 16
times more ethanol, which strongly protects against methanol.)

"The greater toxicity of methanol to man is deeply rooted in the limited
biochemical pathways available to humans for detoxification.
The loss of uricase (EC 1.7.3.3.),
formyl-tetrahydrofolate synthetase (EC 6.3.4.3.) (42)
and other enzymes (18) during evolution sets man apart from all
laboratory animals including the monkey (42).

There is no generally accepted animal model
for methanol toxicity (42, 59).

Humans suffer "toxic syndrome" (54) at a minimum lethal dose
of
The minimum lethal dose of methanol
in the rat, rabbit, and dog is 9.5, 7.0 , and 8.0 g/kg, respectively (43);
ethyl alcohol is more toxic than methanol to these test animals (43)."
*******************************************************

http://groups.yahoo.com/group/aspartameNM/message/1052
DMDC: Dimethyl dicarbonate 200mg/L in drinks adds
methanol 98 mg/L [ becomes formaldehyde in body ]: EU Scientific
Committee on Foods 2001.07.12: Murray 2004.01.22

http://groups.yahoo.com/group/aspartameNM/message/1070
critique of aspartame review, French Food Safety Agency AFSSA
2002.05.07 aspartamgb.pdf (18 pages, in English), Martin Hirsch:
Murray 2004.04.13

http://groups.yahoo.com/group/aspartameNM/message/957
safety of aspartame Part 1/2 12.4.2: EC HCPD-G SCF,
EU Scientific Committee on Food, a whitewash; Murray 2003.01.12

http://groups.yahoo.com/group/aspartameNM/message/1045
http://www.holisticmed.com/aspartame/scf2002-response.htm
Mark Gold exhaustively critiques European Commission Scientific
Committee on Food re aspartame ( 2002.12.04 ): 59 pages, 230 references

http://www.HolisticMed.com/aspartame mgold@holisticmed.com
Aspartame Toxicity Information Center Mark D. Gold
12 East Side Drive #2-18 Concord, NH 03301 603-225-2100
http://www.holisticmed.com/aspartame/abuse/methanol.html
"Scientific Abuse in Aspartame Research"

Gold points out that industry methanol assays were too insensitive to
properly measure blood methanol levels. ]
*******************************************************

http://groups.yahoo.com/group/aspartameNM/message/1302
The Lowdown on Sweet? (Ramazzini Foundation, M Soffritti proof that
aspartame causes cancers), Melanie Warner, The New York Times:
Murray 2006.02.12

http://groups.yahoo.com/group/aspartameNM/message/1303
David L. Katz MD comments briefly with Diane Sawyer on ABC
Good Morning America re Ramazzini aspartame cancer study:
excellent opus at Yale U: mainstream research on aspartame
(methanol, formaldehyde, formic acid) toxicity: Murray 2006.02.14


http://groups.yahoo.com/group/aspartameNM/message/1304
to DL Katz MD, Yale U: M. Soffritti, Ramazzini F., did not mention that
humans are about 10X more vulnerable to aspartame than are rats:
found methanol and formaldehyde carcinogenicity 2002: human ADI
levels must be reduced hugely: Katz: Murray 2006.02.15

http://groups.yahoo.com/group/aspartameNM/message/1237
ubiquitous potent uncontrolled co-factors in nutrition research are
formaldehyde from wood and tobacco smoke and many sources,
including from methanol in dark wines and liquors, in pectins
in fruits and vegetables, and in aspartame: Murray 2006.02.14

As a medical layman, I suggest that evidence mandates immediate
exploration of the role of these ubiquitious, potent formaldehyde
sources as co-factors in epidemiology, research, diagnosis,
and treatment in a wide variety of disorders.

Folic acid, from fruits and vegetables, plays a role by powerfully
protecting against methanol (formaldehyde) toxicity.

Many common drugs, such as aspirin, interfere with folic acid,
as do some mutations in relevant enzymes.

The majority of aspartame reactors are female.

In mutual service, Rich Murray
*******************************************************

cancer in rats at human level of 7 cans daily -- also humans ten times more vulnerable than rats
A 1 kg rat that gets cancers from lifetime daily use of
20 mg aspartame per kg body weight is fed only 20 mg aspartame daily, the amount in 10% of a 12-oz diet soda, just 1.2 oz.

At the same exposure, an average 70 kg human would be drinking 84 oz diet soda, 7 cans daily.

The use reported widely was a dozen daily Diet Cokes for John Edwards, the Democratic candidate for Vice President, and the same for Diet Pepsi for Joe Trippi, Howard Dean's campaign manager.

As always in biochemistry, there is huge individual variation, including reports in mainstream journals of
clients who react severely to a 4 mg dose of aspartame that sweetens Maxalt MLT, an under the tongue migraine
medicine (by getting worse migraines) and to the 6-8 mg
aspartame in a single stick of chewing gum -- since
methanol is 11% of the aspartame, these are levels of methanol ingestion ranging from 0.4 to .08 mg, or
0.01 mg methanol per kg body weight for a 70 kg person,
0.10 mg/kg bw aspartame.

Another fact that is not widely reported is that humans are about ten times more vulnerable to methanol than are rats, so the rats are getting cancers at aspartame levels corresponding to ten times the levels that would cause the same effects in humans, i.e., for humans,
2 mg/kg bw, 140 mg use daily use, 8.4 oz diet soda.

http://groups.yahoo.com/group/aspartameNM/message/870
Aspartame: Methanol and the Public Interest 1984: Monte:
Murray 2002.09.23

Dr. Woodrow C. Monte Aspartame: methanol, and the public health.
Journal of Applied Nutrition 1984; 36 (1): 42-54.
(62 references) Professsor of Food Science [retired 1992]
Arizona State University, Tempe, Arizona 85287
woodymonte@xtra.co.nz
The methanol from 2 L of diet soda, 5.6 12-oz cans, 20 mg/can, is
112 mg, 10% of the aspartame.
The EPA limit for water is 7.8 mg daily for methanol (wood alcohol), a
deadly cumulative poison.
Many users drink 1-2 L daily.
The reported symptoms are entirely consistent with chronic methanol
toxicity. (Fresh orange juice has 34 mg/L, but, like all juices, has 16
times more ethanol, which strongly protects against methanol.)

"The greater toxicity of methanol to man is deeply rooted in the limited
biochemical pathways available to humans for detoxification.
The loss of uricase (EC 1.7.3.3.),
formyl-tetrahydrofolate synthetase (EC 6.3.4.3.) (42)
and other enzymes (18) during evolution sets man apart from all
laboratory animals including the monkey (42).

There is no generally accepted animal model
for methanol toxicity (42, 59).

Humans suffer "toxic syndrome" (54) at a minimum lethal dose
of
The minimum lethal dose of methanol
in the rat, rabbit, and dog is 9.5, 7.0 , and 8.0 g/kg, respectively (43);
ethyl alcohol is more toxic than methanol to these test animals (43)."
*******************************************************


Lethality of Aspartame
I consume more diet soda than I should... probably 120 ounces per day give or take. That has been the case for more than ten years. The fact that I'm writing this makes it pretty clear that the lethality is pretty low. Am I the 'lucky one' who is somehow immune to Nutrasweet. Um, probably not. It's hard to keep this scare going in the face of millions of people enjoying Nutrasweet on a daily basis. Ahhhhh!

aspartame
As usual, the fact that controlled studies fail to find any harm is irrelevant to the anti-chemical crowd.

Only the flawed studies that show what they want to see are legitimate in their eyes.

Seems like Chicken Little to me
I've been around enough 'researchers' to know that a fair number don't seem to have a clue about how to conduct an experiment. Once thing for certain, if you go fishing for tuna because that's what you want to bring home, you'll likely bring home tuna. So when I hear some alleged malady being imposed on the public by evil money mongering corporation, I tend to think of some Chicken Little type that saw "Captain Planet" and thought it real.

Aspartame: Unsafe at any level
They should talk to the people who cannot tolerate aspartame. I happen to be one who cannot tolerate aspartame at any dosage. I recieve migraine type headaches about two to five minutes after consuming the stuff. They persist for about two hours, with the worst for about one hour. Aspartame may be one of the triggers for some of the Lou Gerhigs type dieases I have seen. There are several of my relatives who have reactions to aspartame, one who died from one of those terrible Lou Gehrigs type dieases. I don't know if you that can handle aspartame are one of the lucky ones or one of the unlucky! Time will tell if you really can use aspartame safely or wake up someday and cannot move, swallow or talk. Aspartame could be working in conjunction with other drugs or chemicals in triggering the dieases. In the meantime a warning label hould be placed on anything with aspartame!

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